Cardinals QB Kyler Murray Expected to Miss Sunday vs Colts
Arizona Cardinals quarterback Kyler Murray is expected to be unavailable for Sunday’s matchup against the Indianapolis Colts due to a lingering foot injury, according to multiple sources.
Murray has been limited in practice this week and is not anticipated to play in what could be a pivotal Week 6 contest.
Key of Contents
Injury Details & Practice Status
Murray sustained the foot injury late during the Cardinals’ recent loss to the Tennessee Titans. He returned to the field after initially exiting, but follow-up exams raised concerns.
He skipped practice Wednesday and Thursday, then participated in a limited capacity on Friday—his only practice of the week. These restricted reps further support the expectation that he will not suit up Sunday.
In the team’s internal evaluation, Murray is currently listed as questionable. However, reports from ESPN insiders suggest that the Cardinals anticipate he will be ruled out.
Who Will Start in Murray’s Absence?
With Murray likely sidelined, veteran Jacoby Brissett is expected to take the reins under center for Arizona.
Brissett is no stranger to the Colts organization, having played there from 2017 to 2020, making this a somewhat familiar stomping ground.
He has appeared in 53 career starts over 10 seasons, compiling 53 touchdowns overall. His most recent starts were earlier this year for the New England Patriots.
Arizona’s receiving corps expressed confidence in Brissett’s ability to lead. Marvin Harrison Jr. noted their chemistry in practice, while tight end Trey McBride praised Brissett’s leadership and command of the huddle.
Impact on Cardinals’ Offense & Game Plan
The loss of Kyler Murray presents a significant shift for Arizona’s offense. Known for his dual-threat ability—both passing and scrambling—Murray’s absence limits play-calling flexibility.
Brissett, while a capable journeyman, is more of a traditional pocket passer, so the Cardinals may lean more on quick reads, short passes, and conservative decisions to avoid big turnovers.
Additionally, the Cardinals might emphasize their running game to ease pressure on Brissett, control the clock, and maintain rhythm. Receiver Marvin Harrison Jr. will likely play a larger role in making quick separations and exploiting matchups in space.
Colts vs Cardinals: Game Dynamics & Matchup Implications
The Colts enter the matchup with a 4–1 record, while Arizona is struggling at 2–3. Indianapolis boasts one of the league’s most prolific offenses, averaging over 32 points per game.
In contrast, Arizona’s defense has limited explosive plays and has not allowed a 100-yard rusher all season. But without Murray, Arizona’s offensive ceiling may be lower, placing more burden on defensive performance and situational execution.
The Colts might look to test Brissett early with pressure, disguising coverages and varying blitz packages. Arizona will need crisp quarterback play, smart decision making, and a balanced attack to stay competitive.
Reactions From Inside the Locker Room
Even before Murray’s final status was confirmed, teammates rallied around Brissett. Harrison Jr. praised Brissett’s leadership and chemistry:
“I have full trust in Jacoby … he’s been such a good leader and mentor.”
Tight end Trey McBride echoed that confidence:
“He’s a guy I have full confidence in … he commands the huddle, understands what he’s doing.”
Internally, the coaching staff will adjust game plans, shift checks, and scripting to better suit Brissett’s strengths while mitigating risk.
What This Means for Murray’s Season Outlook
While no definitive timeline has been announced, the cautious handling of Murray’s injury suggests the Cardinals hope to avoid aggravation. If the issue is more serious than a mild sprain, lasting absences could pile up.
Murray’s dual-threat style means he must rely on foot health just as much as arm strength. A foot injury, even a subtle one, can affect mobility, timing, planting mechanics, and risk of further injury.
In the short term, the Cardinals will monitor his recovery daily and may opt for full rest rather than a limited return. The team’s performance over the next few weeks could determine how aggressive they are with his return timeline.
PEOPLE ALSO ASK
Will Kyler Murray play against the Colts?
Current indications strongly point to him being ruled out. Though currently listed as questionable, sources within the team expect he will not take the field Sunday.
Who is starting at QB for the Cardinals if Murray is out?
Jacoby Brissett is projected to start in place of Murray. He has experience in the NFL and familiarity playing in Indianapolis.
How serious is Kyler Murray’s foot injury?
Details are limited. He practiced only in a limited fashion this week and was inactive two days prior. The cautious approach suggests the team is treating it seriously but hopes to avoid prolonged absence.
Does Murray’s absence favor the Colts?
Likely yes. Without Murray’s dual-threat capability, the Cardinals have less offensive flexibility. The Colts, with a dynamic attack, can exploit weaknesses in Arizona’s offense and defense.
Can Arizona still win without Murray?
Yes, though it becomes more challenging. The Cardinals will need excellent execution, game planning, and play from Brissett. Arizona’s defense and running game must also step up.
Additional Analysis & Context
Murray’s Performance to Date in 2025
Through early October, Murray had passed for 962 yards, with six touchdowns and three interceptions. His QBR placed him lower among starters, partly due to inconsistency and pressure situations.
When healthy, Murray’s mobility adds stress to defenses, opening lanes for receivers and creating improvisational opportunities.
Brissett’s Potential Role & Limitations
Brissett’s experience allows for better composure in the pocket, but his strengths lie in short- to intermediate routes and managing the game. The Cardinals should avoid asking him to replicate Murray’s explosiveness.
Expect more three-step throws, checkdowns, and packaged plays that limit exposure to blitzes and hesitation.
Injury Management Strategy
The Cardinals may opt for a stepwise return plan—first full rest, then limited practice, then game action—depending on how Murray’s foot responds. A setback could push him out further than anticipated.
Fantasy Football Implications
Murray’s unavailability negatively impacts his value, while Brissett’s rise may shift target shares to receivers like Harrison Jr. and McBride. Rosters should adjust accordingly.
FAQs (3–5)
Q1: Is Kyler Murray officially ruled out for Sunday?
A: As of now, he remains listed as questionable. But sources within ESPN and the team expect he will not play.
Q2: Could Murray return later this season?
A: Yes—if his foot heals properly. The team is likely to monitor progression and avoid rushing a return, especially for a mobile quarterback whose foot health is critical.
Q3: How might the Cardinals modify their offense without Murray?
A: They’ll likely emphasize the run game more, rely on shorter passing routes, and reduce high-risk throws. Brissett will manage the game rather than improvise.
Q4: Has Brissett ever played in Lucas Oil Stadium before?
A: Yes—Brissett played for the Colts from 2017 to 2020, making this somewhat familiar territory for him.
Q5: What’s the worst-case scenario for Murray’s injury long term?
A: A chronic foot issue could limit his mobility, reduce effectiveness, and require longer-term rest or even surgical intervention depending on severity.